Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Mytilene (68% of total searches to Lesbos). The next most popular destinations are Sigri (18%) and Míthymna (9%). Searches for hotels in Skala Eresou (5%) are also popular.
KAYAK users have found double rooms in Lesbos for as cheap as $44 (Mytilene) in the last 3 days. The average price is $159.