Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Mytilene (71% of total searches to Lesbos). The next most popular destinations are Sigri (19%) and Skala Eresou (5%). Searches for hotels in Skala Kallonis (5%) are also popular.
KAYAK users have found double rooms in Lesbos for as cheap as $43 (Mytilene) in the last 3 days. The average price is $182.