Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Buenos Aires (28% of total searches to South America). The next most popular destinations are Rio de Janeiro (26%) and Santiago (25%). Searches for hotels in Medellín (21%) are also popular.
Based on KAYAK hotel searches, the most popular region to stay in South America is Rio de Janeiro. Capital Federal District and Region Metropolitana are also very popular.
KAYAK users have found double rooms in South America for as cheap as $9 (Santa Marta) in the last 3 days. The average price is $141.